The central pain amplification found with fibromyalgia is similar to complex regional pain syndrome (CRPS).

Both neurological disorders are associated with increase glutamate levels in the brain.

Ketamine targets glutamate and specifically decreases glutamate activity in the brain.

In this 12-minute video, Anthony Kirkpatrick MD PhD reviews the objective clinical data showing a significant improvement of Dr. Jeffrey Johnson's symptoms due to fibromyalgia.


One of the preeminent crises in pain management in the United States today is the lack of evidence for the outcomes of most of the things providers do for patients.

Randomized clinical trials are not the only reliable source of information about treatment utility; they are rarely useful for the assessment of long-term effects, either good or bad. Observational studies do have something to offer.


PART I  ... Basis For Treating Fibromyalgia With Ketamine